Cell degradation detection based on an inter-cell approach

Fault management is a crucial part of cellular network management systems. The status of the base stations is usually monitored by well-defined key performance indicators (KPIs). The approaches for cell degradation detection are based on either intra-cell or inter-cell analysis of the KPIs. In intra-cell analysis, KPI profiles are built based on their local history data whereas in inter-cell analysis, KPIs of one cell are compared with the corresponding KPIs of the other cells. In this work, we argue in favor of the inter-cell approach and apply a degradation detection method that is able to detect a sleeping cell that could be difficult to observe using traditional intra-cell methods. We demonstrate its use for detecting emulated degradations among performance data recorded from a live LTE network. The method can be integrated in current systems because it can operate using existing KPIs without any major modification to the network infrastructure

Säännösteltyjen järvien ekologisen tilan arviointi

Vaikka säännösteltyjä järviä on tutkittu kahden viimeisen vuosikymmenen aikana, ovat aikaisemmissa hankkeissa kerätyt biologiset aineistot hajanaisia ja etenkin lievästi säännöstellyissä järvissä riittämättömiä vesipolitiikan puitedirektiivin edellyttämien vertailuolojen määrittelyyn ja ekologisen tilan luokittelu- ja seurantajärjestelmän kehittämiseen. Tutkimuksen tavoitteena oli tuottaa tietoa säännösteltyjen järvien ekologista luokittelua ja ympäristötavoitteiden määrittämistä varten ottaen huomioon samaan aikaan EU-tasolla ja kansallisesti tapahtuva valmistelutyö vesipuitedirektiivin toimeenpanemiseksi. Osahankkeissa hyödynnettiin olemassa olevia biologisia aineistoja säännöstellyiltä järviltä ja niiden vertailuvesistöistä. Uutta aineistoa kerättiin rantavyöhykkeen kalastosta, rantavyöhykkeen pohjaeläimistöstä ja vesikasvillisuudesta. Työssä kehitettiin luokittelumuuttujia vesienhoitoasetuksen mukaista tilan arviointia varten. Varsinaista luokittelumuuttujien valintaa varten laadittiin vaihtoehtoisia tilan arviointimalleja, joiden perusteella järvien tilaluokka määriteltiin. Vedenkorkeuden säännöstelyn vaikutus näkyi sekä vesikasvillisuudessa, pohjaeläimistössä että rantavyöhykkeen kalastossa. Järvien tilaluokka oli laatutekijästä ja elinympäristöstä riippuen huonompi kuin hyvä, kun vedenkorkeuden talvialenema oli yli 2–3 m. Sekä vesikasvillisuudessa, pohjaeläimistössä että kalastossa oli tunnistettavissa useita säännöstelylle herkkiä lajeja. Vesikasveista säännöstelystä näyttävät kärsivät eniten pohjalehtiset, pohjaeläimistä kaksivuotiset hyönteistoukat ja kaloista mutu ja kivisimppu. Rantavyöhykkeen kalaston, pohjaeläimistön ja vesikasvillisuuden luokitukset poikkesivat useassa säännöstelyjärvessä selvästi toisistaan. Järven yleistilaan vaikuttaa tällöin suuresti, määräytyykö tila kaikkien biologisten laatutekijöiden keskimääräisenä tilana (esim. mediaani) vai heikoimmassa tilassa olevan laatutekijän (ns. heikoimman lenkin menetelmä) mukaan

Early Category-Specific Cortical Activation Revealed by Visual Stimulus Inversion

Visual categorization may already start within the first 100-ms after stimulus onset, in contrast with the long-held view that during this early stage all complex stimuli are processed equally and that category-specific cortical activation occurs only at later stages. The neural basis of this proposed early stage of high-level analysis is however poorly understood. To address this question we used magnetoencephalography and anatomically-constrained distributed source modeling to monitor brain activity with millisecond-resolution while subjects performed an orientation task on the upright and upside-down presented images of three different stimulus categories: faces, houses and bodies. Significant inversion effects were found for all three stimulus categories between 70–100-ms after picture onset with a highly category-specific cortical distribution. Differential responses between upright and inverted faces were found in well-established face-selective areas of the inferior occipital cortex and right fusiform gyrus. In addition, early category-specific inversion effects were found well beyond visual areas. Our results provide the first direct evidence that category-specific processing in high-level category-sensitive cortical areas already takes place within the first 100-ms of visual processing, significantly earlier than previously thought, and suggests the existence of fast category-specific neocortical routes in the human brain

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

<p>Abstract</p> <p>Background</p> <p>Hyaluronan accumulation correlates with the degree of malignancy in many solid tumor types, including malignant endometrial carcinomas. To elucidate the mechanism of hyaluronan accumulation, we examined the expression levels of the hyaluronan synthases (<it>HAS1</it>, <it>HAS2 </it>and <it>HAS3</it>) and hyaluronidases (<it>HYAL1 </it>and <it>HYAL2</it>), and correlated them with hyaluronan content and HAS1-3 immunoreactivity.</p> <p>Methods</p> <p>A total of 35 endometrial tissue biopsies from 35 patients, including proliferative and secretory endometrium (n = 10), post-menopausal proliferative endometrium (n = 5), complex atypical hyperplasia (n = 4), grade 1 (n = 8) and grade 2 + 3 (n = 8) endometrioid adenocarcinomas were divided for gene expression by real-time RT-PCR, and paraffin embedded blocks for hyaluronan and HAS1-3 cytochemistry.</p> <p>Results</p> <p>The mRNA levels of <it>HAS1-3 </it>were not consistently changed, while the immunoreactivity of all HAS proteins was increased in the cancer epithelium. Interestingly, <it>HAS3 </it>mRNA, but not HAS3 immunoreactivity, was increased in post-menopausal endometrium compared to normal endometrium (p = 0.003). The median of <it>HYAL1 </it>mRNA was 10-fold and 15-fold lower in both grade 1 and grade 2+3 endometrioid endometrial cancers, as compared to normal endometrium (p = 0.004-0.006), and post-menopausal endometrium (p = 0.002), respectively. <it>HYAL2 </it>mRNA was also reduced in cancer (p = 0.02) and correlated with <it>HYAL1</it> (r = 0.8, p = 0.0001). There was an inverse correlation between <it>HYAL1 </it>mRNA and the epithelial hyaluronan staining intensity (r = -0.6; P = 0.001).</p> <p>Conclusion</p> <p>The results indicated that <it>HYAL1 </it>and <it>HYAL2 </it>were coexpressed and significantly downregulated in endometrioid endometrial cancer and correlated with the accumulation of hyaluronan. While immunoreactivity for HASs increased in the cancer cells, tumor mRNA levels for <it>HAS</it>s were not changed, suggesting that reduced turnover of HAS protein may also have contributed to the accumulation of hyaluronan.</p

Early Preferential Responses to Fear Stimuli in Human Right Dorsal Visual Stream - A Meg Study

Emotional expressions of others are salient biological stimuli that automatically capture attention and prepare us for action. We investigated the early cortical dynamics of automatic visual discrimination of fearful body expressions by monitoring cortical activity using magnetoencephalography. We show that right parietal cortex distinguishes between fearful and neutral bodies as early as 80-ms after stimulus onset, providing the first evidence for a fast emotion-attention-action link through human dorsal visual stream

Primary and metastatic ovarian cancer: Characterization by 3.0T diffusion-weighted MRI

OBJECTIVES We aimed to investigate whether apparent diffusion coefficients (ADCs) measured by 3.0T diffusion-weighted magnetic resonance imaging (DWI) associate with histological aggressiveness of ovarian cancer (OC) or predict the clinical outcome. This prospective study enrolled 40 patients with primary OC, treated 2011-2014. METHODS DWI was performed prior to surgery. Two observers used whole lesion single plane region of interest (WLsp-ROI) and five small ROIs (S-ROI) to analyze ADCs. Samples from tumours and metastases were collected during surgery. Immunohistochemistry and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to measure the expression of vascular endothelial growth factor (VEGF) and its receptors. RESULTS The interobserver reliability of ADC measurements was excellent for primary tumours ICC 0.912 (WLsp-ROI). Low ADCs significantly associated with poorly differentiated OC (WLsp-ROI P = 0.035). In primary tumours, lower ADCs significantly associated with high Ki-67 (P = 0.001) and low VEGF (P = 0.001) expression. In metastases, lower ADCs (WLsp-ROI) significantly correlated with low VEGF receptors mRNA levels. ADCs had predictive value; 3-year overall survival was poorer in patients with lower ADCs (WLsp-ROI P = 0.023, S-ROI P = 0.038). CONCLUSION Reduced ADCs are associated with histological severity and worse outcome in OC. ADCs measured with WLsp-ROI may serve as a prognostic biomarker of OC. KEY POINTS • Reduced ADCs correlate with prognostic markers: poor differentiation and high Ki-67 expression • ADCs also significantly correlated with VEGF protein expression in primary tumours • Lower ADC values are associated with poorer survival in ovarian cancer • Whole lesion single plane-ROI ADCs may be used as a prognostic biomarker in OC

SIAK – A Game for Foreign Language Pronunciation Learning

Peer reviewe

Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs

Background Carbonic anhydrase (CA) classically catalyses the reversible hydration of dissolved CO2 to form bicarbonate ions and protons. The twelve active CA isozymes are thought to regulate a variety of cellular functions including several processes in the reproductive systems. Methods The present study was designed to investigate the expression of transmembrane CAs, CA IX and XII, in the mouse uterus, ovary and placenta. The expression of CA IX and XII was examined by immunoperoxidase staining method and western blotting. CA II and XIII served as positive controls since they are known to be present in the mouse reproductive tract. Results The data of our study indicated that CA XII is expressed in the mouse endometrium. Only very faint signal was observed in the corpus luteum of the ovary and the placenta remained mainly negative. CA IX showed weak reaction in the endometrial epithelium, while it was completely absent in the ovary and placenta. Conclusion The conservation of CA XII expression in both mouse and human endometrium suggests a role for this isozyme in reproductive physiology.BioMed Central open acces